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Welcome to the Fall 2017 issue of Progressnotes

Progressnotes is the quarterly magazine of the Medical University of South Carolina. Our mission is to keep you abreast of the latest clinical and scientific innovations through engaging and scientifically sophisticated prose. Browse our latest articles below and sign up for electronic notifications of exclusive digital-only content and published-ahead-of-print content.


In Short

In Short articles concisely describe innovative procedures, diagnostic tools, or treatment approaches available at MUSC Health, sometimes as part of a clinical trial, and summarize preliminary findings from MUSC research.

A New Wrinkle

Mysterious protein-folding molecule could trigger metabolic disorders

stAGEs of Cancer

Grape compound could reduce cancer-linked molecule in the diet

First of Its Kind

Novel inhibitor shown safe in first-in-kind phase 1 trial at Hollings Cancer Center

From Bed to Bench and Back to Bed

A synthetic peptide designed to treat HPV-negative cancer



Feature articles explore a clinical or research innovation at MUSC in some depth, highlighting how it advances or could potentially expand treatment options over traditional therapy.

Frontiers in Neuroblastoma Treatment

MUSC Children’s Health is conducting pioneering clinical trials on upfront precision medicine therapy and relapse prevention for neuroblastoma

First Act

FDA approves the first-ever genetically modified adoptive cell transfer therapy for pediatric acute lymphoblastic leukemia

Neoantigens: Cancer's Achilles Heel?

A multidisciplinary team of MUSC investigators is working at the interface of immunotherapy and genetics to expand treatment options for patients with lung cancers

Same Gain, Less Pain

Video-assisted thoracoscopic surgery achieves similar outcomes to thoracotomy in stage 1 non-small cell lung cancer with less pain, fewer complications and quicker recovery

A Conversation About Palliative Care

Progressnotes talks with three members of the expanded palliative care team

The RNA Family

A group of experts has formed at MUSC to study the roles of different RNAs in cancer



Progressnotes CME Articles

Progressnotes is pleased to offer continuing education opportunities in an effort to meet the educational needs of our audience of health care professionals and to address the health care challenges of South Carolina, particularly its high burden of chronic illness. Each issue of Progressnotes, with the exception of the Year in Review, will offer one CME-eligible article along with a sister telepresentation on a related subject through the South Carolina Area Health Education Consortium’s SCHOOLS program. The telepresentation is typically scheduled within a month or so of the article’s publication, recorded as enduring CME, and made available at

A Question of Timing

Rethinking treatment sequencing in metastatic prostate cancer