Doctor/Provider Profile

Terrence X. O'Brien, M.D., M.S., FACC

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  • Professor
Degree M.D., M.S., FACC
School M.D. awarded by University of California, San Diego, 1984; M.S. in Biological Sciences awarded by Stanford University, 1980
  • University of Texas Southwestern Medical Center, Dallas
  • University of California Medical Center and Veterans Administration Medical Center, San Diego
Board Certification
  • Internal Medicine
  • Internal Medicine: Cardiovascular Disease
  • Cardiology
Clinical Interests
  • Clinical cardiology
  • Congestive heart failure
  • Echocardiography
Accepts New Patients Yes
To request an appointment call our representatives at 843-792-1414


MUSC Health East Cooper
1600 Midtown Ave.
Mount Pleasant, SC 29464
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Ashley River Tower
25 Courtenay Drive
Charleston, SC 29425
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Dr. O’Brien is board certified in Cardiovascular Medicine and Internal Medicine.  He is a graduate of the University of California, San Diego School of Medicine. His undergraduate degree is in Chemistry and he has a Master’s Degree in Biological Sciences, both at Stanford University. Dr. O’Brien did his Internal Medicine Residency at Southwestern Medical Center in Dallas (Parkland Hospital), a clinical Cardiology Fellowship at the University of California, San Diego where he also did a research Cardiology Fellowship in Molecular Cardiology as a Bugher Fellow.  Dr. O’Brien is currently Professor of Medicine and Cell Biology and Anatomy at the Medical University of South Carolina where he has been since 1993. 

Dr. O’Brien’s clinical interests include all aspects of inpatient and outpatient general cardiology. He sees scheduled patients at MUSC downtown as well as at the MUSC Outreach Cardiology Clinic in East Cooper, where he is the Medical Director.

Dr. O’Brien also serves as the Director of the Echocardiography Laboratory at the Ralph H. Johnson Department of Veteran's Affairs Medical Center in Charleston and is the Director of Clinical Cardiovascular Research at the Medical University of South Carolina. 

Dr. O’Brien's research career has involved both basic laboratory research examining the mechanisms of heart hypertrophy and failure as well as participation in human clinical trials evaluating new medications and diagnostic techniques in patients with various forms of heart failure.

Dr. O’Brien is the author of over 45 peer reviewed publications.  He is a member of a number of professional societies including the American Society of Echocardiography, the American Heart Association, the American College of Cardiology, the Heart Failure Society of America, the International Society for Heart Research, and the Southern Society for Clinical Investigation. Dr. O’Brien’s research has been supported by grants from the National Heart, Lung and Blood Institute, the Department of Veterans Affairs, the American Heart Association, the Medical University of South Carolina and numerous other sponsors.

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