Dr. O’Brien is board certified in Cardiovascular Medicine and Internal Medicine. He is a graduate of the University of California, San Diego School of Medicine. His undergraduate degree is in Chemistry and he has a Master’s Degree in Biological Sciences, both at Stanford University. Dr. O’Brien did his 3-year Internal Medicine Residency at Southwestern Medical Center in Dallas (Parkland Hospital), a 3-year clinical Cardiology Fellowship at the University of California, San Diego where he also did a 2-year research Cardiology Fellowship in Molecular Cardiology as a Bugher Fellow. Dr. O’Brien is currently Professor of Medicine and Regenerative Medicine at the Medical University of South Carolina where he has been since 1993.
Dr. O’Brien’s clinical interests include all aspects of inpatient and outpatient general cardiology including coronary disease, heart failure, valvular disorders, lipid management, arrhythmias and prevention. He sees scheduled patients at MUSC downtown as well as at the MUSC Cardiology Clinic in East Cooper, where he is the Medical Director.
Dr. O’Brien's research career has involved both basic laboratory research examining the mechanisms of heart hypertrophy and failure as well as participation in human clinical trials evaluating new medications and diagnostic techniques in patients with various forms of heart failure.
Dr. O’Brien is the author of over 55 peer reviewed publications. He is a member of a number of professional societies including the American Society of Echocardiography, the American Heart Association, the American College of Cardiology, the Heart Failure Society of America and the International Society for Heart Research. Dr. O’Brien’s research has been supported by grants from the National Heart, Lung and Blood Institute, the Department of Veterans Affairs, the American Heart Association, the Medical University of South Carolina and numerous other sponsors.